Please just make sure you support arbitrary controllers, and hopefully diff. profiles will be possible depending on the vehicle (or foot) you're in. Oh, and TrackIR, TrackIR, TrackIR. Mhh ok? :-)
On a sidenode, I recently purchased 2 games, Just Cause 2 and Mafia II, and guess what, both only support the XBox 360 controller. WTF, when did that trend start to happen. Now you need to use some sort of external xbox controller fake program to get your joystick to work. This is rediculouse. I first noticed it when I bought GTA IV a while ago, Gaming for Windows my ass, more like gaming for XBox controller.
Sorry for the little rant.