Well I didn't get into clashes with it myself, but heard reports of the problem from multiple sides, including my bro's, so I'm a bit at unease about it in advance. But yea, when I think about it, it should not be a problem of apps, just the drivers. But since OT is so sensitive about the drivers, I expect a lot of problems coming indirectly here. We'll have to detect driver versions that work, and announce to the user that they need to update or else nothing works. Updating means finding the right version for whatever ABI there's now, whenever the kernel updates and breaks stuff because for some reason there cannot be a stable ABI for graphics cards.
At least Linux users are used to it, so when OT doesn't work and we print that it's a driver problem, they will go and fix it (hopefully). Unlike when we print it on Windows, a large part of people still think OT is faulty because their other games work, why can't OT? We will have to do lots more of problem detection and auto-repair attempts to reduce the number of failed attempts to run OT, that is currently very high.