Another strange and uncommon idea for another game...Yea, blame me, but dont' flame...
Anterra
Ants - either black, red or brown...Neither always liked each other - that's not a surprise. But now brawling colonies of little bugs will have to join their forces, because new enemy is coming...
In Anterra, you take control of an ant colony and you are given control of all individual ants - workers, soldiers and the queen.
You have to manually build your anthill and dig tunnels, getting resources to improve your "fortress", because your enemies don't sleep - but they will also have to build their colonies.
With use of terrain destructability, one could be able to build nearly limitless anthills, able to be many meters wide (note: the character scale is really small - proportional to rest of the world - that's why it could be meters).
But ants wouldn't be the only possibility - what about bees, hoppers or these enormous singularities, like mantises?
You will see that microuniverse is no less interesting that ours!
Quite stupid and far-fetched, isn't it?
Sandbox in mini-scale, essentially.