I'm going to start off with an interesting one. Antonio Nariño Airport (IATA: PSO, ICAO: SKPS) is located in the town of Chachagüí (columbia) and serves the city of Pasto:
(A town which which is located 35km away from the airport. The airport only handles domestic flights in addition to military operations and private charters)
Elevation AMSL: 5.951 ft
The airport's runway was built on a plateau of 50 meters because of the surrounding terrain. Due to this, many pilots refer to the airport as an aircraft carrier. The runway is also relatively short for the altitude at which the airport is at.
The position of the runway means that it is often rendered useless since, in the presence of crosswinds, it prevents aircraft making a safe take off and landing. Crosswinds are common during the summer, particularly during the month of August.